Immunology

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome

Vaccine design depends on knowing which viral regions are actually seen by T cells and whether those regions remain stable as the virus evolves. This study maps immunodominant SARS-CoV-2 T cell epitopes and examines their relationship to evolutionary conservation.

Published article2025

Cansu Cimen Bozkus, Matthew Brown, Leandra G. Velazquez, Marcus Thomas, Eric A. Wilson, Timothy O'Donnell, Anna Kaminska, Denis Ruchnewitz, Douglas Geertz, Yonina Bykov, Julia Kodysh, Kasopefoluwa Y. Oguntuyo, Vladimir Roudko, David Hoyos, Komal D. Srivastava, Giulio Kleiner

RecordDOIPubMedPreprint

This study maps immunodominant T cell epitopes across the SARS-CoV-2 proteome and analyzes their relationship to evolutionary conservation.

The work supports the design of next-generation vaccines targeting conserved viral regions that may preserve T cell immune surveillance across emerging variants.